Academic Research

Professor Sheng-Yang Wang used a chronic mild stress (CMS)-induced mouse model to investigate the potential antidepressant effects of fruit extract (CD) and essential oil (CDE) derived from Hirami lemon (Citrus reticulata var. depressa) peel, and further analyzed their association with changes in the gut microbiome. The results showed that oral administration of CDE and CD significantly reversed CMS-induced depression- and anxiety-like behaviors in mice. The study also identified 25 compounds in CD and 11 terpenoid compounds in CDE. These findings demonstrate the potential of Hirami lemon as a natural source of antidepressant agents for the prevention and treatment of major depressive disorder. The study was published in Food & Function (Tsai et al., 2023).

Article source: https://pubs.rsc.org/en/content/articlehtml/2023/6z/d3fo01301d