Academic Research

Professor Cheng-Chung Chang, Professor Gou-Jen Wang, and their team developed an M3D-SERS chip, a highly sensitive multilayer three-dimensional single-component SERS substrate fabricated by layer-by-layer stacking of silver nanowires. Finite integration technique simulations showed that intensely localized plasmonic hotspots generated in nanogaps were responsible for the enhanced SERS performance. The M3D-SERS chip enabled nanomolar-level detection of biomolecules, including bovine serum albumin and SARS-CoV-2-related antigens and antibodies, demonstrating strong potential for clinical biosensing applications. The study was published in Applied Physics Reviews (Sahoo et al., 2023).

Article source: https://pubs.aip.org/aip/apr/article/10/4/041403/2916154