[Shih-Shun Lin and Choun-Sea Lin] Study on HC-Pro-Mediated Inhibition of HEN1 Methyltransferase Activity Leading to the Autophagic Degradation of AGO1
Professor Shih-Shun Lin, Professor Choun-Sea Lin, and their research teams compared the differences in RNA silencing suppression mediated by HC-Pro proteins from different potyviruses, revealing diverse mechanisms underlying the regulation of miRNA methylation and RNA-induced silencing complex (RISC) function. Their study showed that HC-Pro from different potyviruses exhibits distinct capacities to inhibit HEN1 methyltransferase activity, with corresponding differences in unmethylated miRNA accumulation and AGO1 autophagic degradation. These findings provide new insight into the functional diversity of HC-Pro in modulating RNA silencing pathways. The research was published in Nature Communications (Pan et al., 2025).
Article source: https://www.nature.com/articles/s41467-025-56320-z